The effects of hemoglobin solutions on renal functions in man.

By J. LEONARD BRANDT, M.D., N. ROBERT FRANK, M.D. AND IIEntnnEriT C. LICHTMAN, M.D. T HE USE of hemoglobini solutionis as a possible plasma sush)stitunte ins shock, hypoproteinmemia annd other diseases has heens suggested. Normally this material ins the form of red cells is discarded ins the prepan-atious of plasma ansd its fract-ionss. rfhat hemoglobins may be adminsist-ered inn large quantities w-ithout urstoward results has beets reported, despite the familiar’ scquelae of inensoglobinnuria ins diseased states.’ There are usumerous reports oun tine circulaton-y effects of innfusionns of salinne, plasma, gelatins anid si’hole bloo(l.24 \en-y few of these reports give any extennsive data on the rensal hemodynnamic alterationns inscideust to the administrations of the particular material inmfused. Because of tine well knnossni renal arid geineral vascular alteratiouss accompanmyinng shock5 tunic! incompatible blood trasssfusious6 it si-as thought ads-isable to study the renial dynnamic and some genseral vascular effects of innfusionss of hemoglobins soltrtionns ins maui. Studies of the effects ons renial hemodynnamics of lsemoglobinn soluti()ns acimiusistered to ausimals has-c beets reported.7 .